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MR-guided focused ultrasound technique in functional neurosurgery: targeting accuracy

David Moser1*, Eyal Zadicario2, Gilat Schiff2 and Daniel Jeanmonod1

Author Affiliations

1 Center of Ultrasound Functional Neurosurgery, Leopoldstrasse 1, Solothurn, CH-4500, Switzerland

2 InSightec Ltd, Tirat Carmel, 39120, Israel

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Journal of Therapeutic Ultrasound 2013, 1:3  doi:10.1186/2050-5736-1-3

Published: 25 April 2013



The purpose of this study was to describe targeting accuracy in functional neurosurgery using incisionless transcranial magnetic resonance (MR)-guided focused ultrasound technology.


MR examinations were performed before and 2 days after the ultrasound functional neurosurgical treatment to visualize the targets on T2-weighted images and determine their coordinates. Thirty consecutive targets were reconstructed: 18 were in the central lateral nucleus of the medial thalamus (central lateral thalamotomies against neurogenic pain), 1 in the centrum medianum thalamic nucleus (centrum medianum thalamotomy against essential tremor), 10 on the pallido-thalamic tract (pallido-thalamic tractotomies against Parkinson's disease), and 1 on the cerebello-thalamic tract (cerebello-thalamic tractotomy against essential tremor). We describe a method for reconstruction of the lesion coordinates on post-treatment MR images, which were compared with the desired atlas target coordinates. We also calculated the accuracy of the intra-operative target placement, thus allowing to determine the global, planning, and device accuracies. We also estimated the target lesion volume.


We found mean absolute global targeting accuracies of 0.44 mm for the medio-lateral dimension (standard deviation 0.35 mm), 0.38 mm for the antero-posterior dimension (standard deviation 0.33 mm), and 0.66 mm for the dorso-ventral dimension (standard deviation 0.37 mm). Out of the 90 measured coordinates, 83 (92.2%) were inside the millimeter domain. The mean three-dimensional (3D) global accuracy was 0.99 mm (standard deviation 0.39 mm). The mean target volumes, reconstructed from surface measurements on 3D T1 series, were 68.5 mm3 (standard deviation 39.7 mm3), and 68.9 mm3 (standard deviation 40 mm3) using an ellipsoidal approximation.


This study demonstrates a high accuracy of the MR-guided focused ultrasound technique. This high accuracy is due not only to the device qualities but also to the possibility for the operator to perform on-going real-time monitoring of the lesioning process. A precise method for determination of targeting accuracy is an essential component and basic requirement of the functional neurosurgical activity, allowing an on-going control of the performed therapeutic work indispensable for any target efficiency analysis and the maintenance of a low risk profile.

Anterior commissure; Posterior commissure; Stereotactic atlas; Targeting accuracy; Thalamo-ventricular border; Transcranial MR-guided focused ultrasound